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Reaction chemistry of nitrogen-containing molecules

The Murakami Laboratory conducts research on the construction and modification of nitrogen-containing molecules based on reaction chemistry using transition metal catalysts and photocatalysts. Among nitrogen-containing molecules, we focus on "polyamines" having multiple nitrogen atoms and "ammonium salts" having cationic properties, which are still lagging behind in the progress of reaction chemistry. We also aim to create new biologically active molecules by pursuing the functions of the new nitrogen-containing compounds obtained here.

Synthesis and conversion of polyamines

Polyamines have several nitrogen atoms in the molecules. It is known that polyamines are biologically active molecules, which are involved in many biological phenomena. In this study, we will synthesize structurally new polyamines through the development of new catalytic reactions and modular synthesis.

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Derivation of ammonium compounds

The ammonium skeleton, which has a cation charge on the nitrogen atom, is included in many important molecules, such as bioactive molecules, surfactants, and organocatalysts due to its unique physical properties. However, there are few methods for synthesizing ammonium compounds, and the chemical space of ammonium compounds has not been fully exploited. In our laboratory, we develop an editiing method of ammonium skeletons and pursue new science pioneered by ammonium molecules.

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Reaction development-based chemical library

We are leading the discovery of new bioactive molecules with a chemical library that is constructed through reaction development. Unlike natural product libraries, reaction products have a relatively simple structure. As the reactions have developed by us, a structure-activity relationship (SAR) study can be easily performed. Our laboratory has a large number of polyamines and ammonium salts, which can be provided as collaborative research. New biological activities have been already found in the reaction products.

We will verify the usefulness of this new focused library as a reaction development-based chemical library, which is different from natural product libraries and diversity-oriented synthesis libraries.

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